artesunate
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Indications
* 1st line treatment for severe malaria in U.S.[2]
Dosage
- oral therapy for uncomplicated malaria
- in combination with mefloquine 25 mg/kg
- 10-12 mg/kg given in divided doses over 3-5 days
- 4 mg/kg for 3 days
- 4 mg/kg, followed by 1.5 mg/kg for 5 days
- 10-12 mg/kg given in divided doses over 3-5 days
- used alone
- 10 to 12 mg/kg given in divided doses over 7 days
- 4 mg/kg, followed by
- 2 mg/kg on days 2 & 3 & 1 mg/kf on days 4-7
- 10 to 12 mg/kg given in divided doses over 7 days
- in combination with mefloquine 25 mg/kg
- parenteral therapy for severe disease
Pharmacokinetics
most rapidly-acting antimalarial agent
Adverse effects
- remarkably few
- neurotoxicity reported in animals
Mechanism of action
- derivative of Chinese drug ginghao
More general terms
Additional terms
References
- ↑ Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1186-87
- ↑ 2.0 2.1 CDC News Release. March 28, 2018 CDC: Artesunate Now First-Line Treatment for Severe Malaria in the United States. https://www.cdc.gov/media/releases/2019/s0328-artesunate-first-line-treatment.html CDC's malaria hotline (770-488-7788) to obtain artesunate