artesunate

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Indications

malaria*

* 1st line treatment for severe malaria in U.S.[2]

Dosage

  • oral therapy for uncomplicated malaria
    • in combination with mefloquine 25 mg/kg
      • 10-12 mg/kg given in divided doses over 3-5 days
        • 4 mg/kg for 3 days
        • 4 mg/kg, followed by 1.5 mg/kg for 5 days
    • used alone
      • 10 to 12 mg/kg given in divided doses over 7 days
        • 4 mg/kg, followed by
        • 2 mg/kg on days 2 & 3 & 1 mg/kf on days 4-7
  • parenteral therapy for severe disease
    • 2.4 mg/kg IV or IM, followed by
    • 1.2 mg/kg & 12 & 24 h, then
    • 1.2 mg/kg QD

Pharmacokinetics

most rapidly-acting antimalarial agent

Adverse effects

Mechanism of action

  • derivative of Chinese drug ginghao

More general terms

Additional terms

References

  1. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1186-87
  2. 2.0 2.1 CDC News Release. March 28, 2018 CDC: Artesunate Now First-Line Treatment for Severe Malaria in the United States. https://www.cdc.gov/media/releases/2019/s0328-artesunate-first-line-treatment.html CDC's malaria hotline (770-488-7788) to obtain artesunate

Database