trientine (Cuprid, Tecza, Syprine)

Introduction

Trientine hydrochloride. N,N'-bis (2-aminoethyl-1,2-ethane-diamine dihydrochloride [NH2-(CH2)2-NH-(CH2)2-NH-(CH2)2-NH2] * 2HCl C6H18N4 * 2HCl

Indications

• hepatolenticular degeneration (Wilson's disease)
• not recommended for rheumatoid arthritis or cystinuria

Dosage

• start: 750-1250 mg QD divided TID or QID; max: 2 g/day
• start: 500-750 mg PO QD in children; max 1.5 g/day
• take on empty stomach
  • 1 hour before meals, or 2 hours after meals
• average effective daily dose: 1-2 g

Capsules: 250 mg

Adverse effects

• iron deficiency
• recurrence of prior symptoms of lupus erythematosus
• pregnancy category C: teratogenic in rats

Mechanism of action

copper chelation

More general terms

• amine
• chelating agent

Additional terms

• hepatolenticular degeneration; Wilson's disease

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5565
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=71433
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=71434