trientine (Cuprid, Tecza, Syprine)

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Introduction

Trientine hydrochloride. N,N'-bis (2-aminoethyl-1,2-ethane-diamine dihydrochloride [NH2-(CH2)2-NH-(CH2)2-NH-(CH2)2-NH2] * 2HCl C6H18N4 * 2HCl

Indications

Dosage

  • start: 750-1250 mg QD divided TID or QID; max: 2 g/day
  • start: 500-750 mg PO QD in children; max 1.5 g/day
  • take on empty stomach
    • 1 hour before meals, or 2 hours after meals
  • average effective daily dose: 1-2 g

Capsules: 250 mg

Adverse effects

Mechanism of action

copper chelation

More general terms

Additional terms

References

  1. Physician's Desk Reference (PDR) 42nd edition 1998

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