niclosamide (Niclocide, Clonitralid, Bayluscide)

Introduction

Tradename: Niclocide.

Indications

• treatment of intestinal tapeworms
  • beef tapeworm
  • fish tapeworm
  • dwarf tapeworm

Dosage

• beef tapeworm & fish tapeworm
  • adults: 2 g (4 tablets) as single dose
  • children:
    • 11-34 kg: 1 g as single dose
    • > 34 kg: 1.5 g as single dose
• dwarf tapeworm
  • adults: 2 g in a single daily dose for 7 days
  • children:
    • 11-34 kg: 1 g chewed thoroughly in a single dose on day 1, then 500 mg QD for 6 days
    • > 34 kg: 1.5 g as single dose on day 1, then 1 g QD for 6 days

Tablets: (chewable) 500 mg.

Adverse effects

• not common (1-10%)
  • drowsiness, dizziness, headache, nausea/vomiting, loss of appetite, diarrhea
• uncommon (< 1%)
  • palpitations, edema in the arm, rash, pruritus ani, alopecia, oral irritation, fever, taste disturbance*, constipation, rectal bleeding, weakness, backache, diaphoresis

* bad taste in mouth

More general terms

• antihelmintic

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4477
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=14992