triptorelin (Trelstar LA)

Introduction

Tradename: Trelstar. (triptorelin pamoate)

Indications

• depohormone for treatment of advanced prostate cancer
• precocious puberty
• endometriosis

Dosage

IM injection every 3 months

Mechanism of action

• GnRH analog
• affects LH & FSH release from the pituitary
  • initially stimulates LH & FSH release, then
  • diminishes LH & FSH release via negative feed-back (loss of pulsatility)
• decline in testosterone & estradiol production
• causes chemical castration
• retards growth of hormone-sensitive tissue

Manufacturer: Debiopharm

More general terms

• gonadotropin-releasing hormone agonist (GnRH analog)
• antineoplastic endocrine agent
• peptide