Auer rod
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Etiology
- Auer rods can be found in any of the subtypes of AML, but they are especially with
- AML M1 (acute myleloid leukemia)
- AML M3 (acute promyelocytic leukemia)
Pathology
- Auer rods are linear or spindle-shaped red-purple inclusion in myeloblasts or promyelocytes stained with Romanowsky stain.
- Less commonly, they may be seen in more mature neutrophils.
- Their presence is pathognomonic for the diagnosis
- acute myleloid leukemia (AML) or
- refractory anemia with excess blasts in transformation
- Auer rods are derivatives of azurophilic granules & stain positively for Sudan Black B, myeloperoxidase, ASD chloroacetate esterase, & acid phosphatase
More general terms
References
- ↑ Clinical Diagnosis & Management by Laboratory Methods, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1991, pg 692