Lewy body variant of Alzheimer's disease (AD)

^[1]^[2]

Introduction

A form of AD characterized by the presence of Lewy bodies & Hirano bodies. Amyloid plaques are present in the usual abundance (in contrast to diffuse Lewy body disease); however, neurofibrillary tangles are few in number.

It is considered by some to be one & the same as diffuse Lewy body disease (Lewy body dementia)^[1]. Others^[2] consider it a separate entity.

↑ ^1.0 ^1.1 Bruce Miller, M.D., UCSF Memory & Aging Center, 2001
↑ ^2.0 ^2.1 Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11274343