bovine spongiform encephalopathy; mad cow disease; BSE

^[1]^[2]^[3]^[4]^[5]

Comparative biology

prion disease of cattle which has resulted in transmission to 100 young adults in Great Brittain & Europe
the disease in humans is variant Creutzfeldt-Jakob disease (vCJD)
in cattle with mad cow disease, tissues other than CNS shown to be infectious:
- retina
- trigeminal & paraspinal ganglia
- distal ileum
- bone marrow (possibly)^[3]

↑ Journal Watch 21(18):147, 2001
↑ Korth C et al Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease. Proc Natl Acad Sci USA 98:9836, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11504948
↑ ^3.0 ^3.1 Brown P. Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease. BMJ 322:841-4, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11290640
↑ Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009
↑ National Institute of Environmental Health Sciences (NIEHS) http://www.niehs.nih.gov/external/faq/madcow.htm