squamous cell carcinoma in situ (Bowen's disease)
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Introduction
A solitary slowly enlarging erythematous plaque with a sharp border & little infiltration.
Etiology
- ultraviolet radiation
- ingestion of inorganic trivalent arsenic
Pathology
Clinical manifestations
- solitary slowly enlarging erythematous plaque with a sharp border & little infiltration
- generally slight scaling & some crusting
- no fine thread-like border as occurs in superficial basal cell carcinoma
- circumscribed erythematous or pigmented patches with keratotic surface[3]
Management
- cryotherapy with liquid nitrogen
- topical 5-fluorouracil
- topical imiquimod[2]
More general terms
Additional terms
References
- ↑ Color Atlas and Synopsis of Clinical Dermatology, Common and Serious Diseases, 3rd ed, Fitzpatrick et al, McGraw Hill, NY, 1997, pg 223
- ↑ 2.0 2.1 Morton CA, Birnie AJ, Eedy DJ. British Association of Dermatologists' guidelines for the management of squamous cell carcinoma in situ (Bowen's disease) 2014. Br J Dermatol. 2014 Feb;170(2):245-60 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24313974
- ↑ 3.0 3.1 Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022