adult granulosa cell tumor

Epidemiology

• account for ~1-5% of all ovarian tumors
• account for ~95% of granulosa cell tumors
• occur more often in post-menopausal women
  • peak incidence ~50-55 yrs.
• most common estrogenic ovarian tumor

Microscopic pathology

• variable microscopic patterns:
  • microfollicular - contain small cavities simulating Call-Exner bodies of developing graafian follicle
  • macrofollicular
  • insular
  • trabecular
  • solid-tubular
  • hollow-tubular
  • moire silk or diffuse pattern associated with poorer differentiation
• nuclei relatively uniform, pale, some with nuclear groove
• variable amounts of theca cells
• mitoses variable, usually not pronounced

Genetics

• may be associated with 402C->G point mutation in the FOXL2 gene

More general terms

• granulosa cell tumor