FLVRES motif

Introduction

The only invariant residue in SH2 domains is an Arg which forms hydrogen bonds with 2 pTyr oxygens. The Arg is contained within the FLVRES motif, a Ser phosphorylation site in which phosphorylation may inhibit SH2-pTyr interactions.

More general terms

• peptide motif
• binding site
• cytoplasmic motif