WW domain-containing oxidoreductase (WWOX) gene

Introduction

16q23.3-q24.1

Pathology

• the gene spans the 2nd most common chromosomal fragile site (FRA16D) which is frequently altered in cancers
• alteration of expression & expression of some isoforms is associated with cancers
• however, it is unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect

More general terms

• unclassified gene

Database

• OMIM: https://mirror.omim.org/entry/133239
• OMIM: https://mirror.omim.org/entry/605131
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51741