tribbles homolog 2 2 (TRB-2, TRIB2, TRB2)

Function

• interacts with MAPK kinases
• regulates activation of MAP kinases (inhibitory)
• no kinase activity

Structure

• belongs to the tribbles family
• contains 1 protein kinase domain

Compartment

cytoplasm, may associate with cytoskeleton

Expression

• highly expressed in peripheral blood leukocytes

Pathology

• antibodies against TRIB2 are present in sera from patients with autoimmune uveitis

More general terms

• enzyme inhibitor
• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q92519.html