paraneoplastic photoreceptor retinal degeneration; paraneoplastic retinopathy

Etiology

• mediator: anti-CAR (recoverin)
• associated neoplasms:
  • small cell lung cancer
  • cervical cancer (rare)

Pathology

• loss of rods & cones
• infiltration of retina with mononuclear cells

Clinical manifestations

• evolution over weeks to months
• painless visual loss
• progression to blindness

More general terms

• paraneoplastic syndrome
• retinal disease

Additional terms

• anti-Hu antibody (type-1 ANNA)
• hippocampal 38K autoantigen