Na+/K+/Ca+2 exchanger 4; Na+/K+/Ca+2-exchange protein 4; solute carrier family 24 member 4 (SLC24A4, NCKX4)

Function

• transports 1 Ca+2 & 1 K+ in exchange for 4 Na+

Structure

• belongs to the Na+/K+/Ca+2 exchanger family, SLC24A subfamily

Compartment

membrane

Alternative splicing

named isoforms=4

Expression

• expressed abundantly in all regions of the brain, aorta, lung & thymus
• expressed at lower levels in the stomach & intestine

Polymorphism

• genetic variations in SLC24A4 are associated with skin/hair/eye pigmentation type 6

Notes

uncertain whether Met-1 or Met-18 is the initiator

More general terms

• solute carrier family 24 (SLC24, SLC24A)
• transmembrane 10e protein
• glycoprotein
• Na+/K+/Ca+2 antiporter or exchanger

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=123041
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:123041
• OMIM: https://mirror.omim.org/entry/210750
• OMIM: https://mirror.omim.org/entry/609840
• UniProt: http://www.uniprot.org/uniprot/Q8NFF2.html