mitochondrial 2-oxoglutarate/malate carrier protein; OGCP; solute carrier family 25 member 11 (SLC25A11 SLC20A4)

Function

• catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids
• plays a role in several metabolic processes, including:
  • malate-aspartate shuttle
  • oxoglutarate/isocitrate shuttle
  • gluconeogenesis from lactate
  • nitrogen metabolism

Structure

• belongs to the mitochondrial carrier family
• contains 3 solcar repeats

Compartment

mitochondrial inner membrane

More general terms

• mitochondrial membrane protein
• regulatory molecule
• solute carrier family 25 (SLC25, SLC25A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8402
• OMIM: https://mirror.omim.org/entry/604165
• UniProt: http://www.uniprot.org/uniprot/Q02978.html