Rab3 GTPase-activating protein

Function

• converts active Rab3-GTP to the inactive form Rab3-GDP
• required for normal eye & brain development
• neurodevelopmental processes
  • proliferation, migration & differentiation before synapse formation
  • nonsynaptic vesicular release of neurotransmitters
• interacts with DMXL2

Structure

• catalytic (RAB3GAP1) & non-catalytic (RAB3GAP2) subunits

More general terms

• molecular complex