Rab3 GTPase-activating protein non catalytic subunit (Rab3 GTPase-activating protein 150 kD subunit, Rab3-GAP p150, Rab3-GAP regulatory subunit, RAB3-GAP150, RGAP-iso, RAB3GAP2, KIAA0839)

Function

• regulatory subunit of a GTPase activating protein
• required for normal eye & brain development
• may participate in neurodevelopmental processes such as proliferation, migration & differentiation before synapse formation, & non-synaptic vesicular release of neurotransmitters

Structure

belongs to the Rab3-GAP regulatory subunit family

Compartment

• cytoplasm
• in neurons, it is enriched in the synaptic soluble fraction

Alternative splicing

named isoforms=2

Expression

ubiquitous

Pathology

• defects in RAB3GAP2 are the cause of Martsolf syndrome

More general terms

• phosphoprotein
• enzyme regulatory subunit

Component of

• Rab3 GTPase-activating protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2578
• OMIM: https://mirror.omim.org/entry/212720
• UniProt: http://www.uniprot.org/uniprot/Q9H2M9.html