QACQG

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Introduction

Variation of conserved pentapeptide motif at the active site of the ICE family of cysteine proteases present in MACH/FLICE.

More general terms

References

  1. Boldin MP, Goncharov TM, Goltsev YV, Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell. 1996 Jun 14;85(6):803-15. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8681376
  2. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. Cell. 1996 Jun 14;85(6):817-27. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8681377