aquaporin-9; AQP-9; small solute channel 1 (AQP9, SSC1)

Function

• forms a channel with a broad specificity
• mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, & pyrimidines in a phloretin- & mercury-sensitive manner, whereas amino acids, cyclic sugars, Na+, K+, Cl-, & deprotonated monocarboxylates are excluded
• also permeable to urea but not to glycerol

Structure

• aquaporins contain two tandem repeats each containing 3 membrane-spanning domains & a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)
• belongs to the MIP/aquaporin (TC 1.A.8) family

Compartment

membrane

Expression

• highly expressed in peripheral leukocytes
• also expressed in liver, lung, & spleen

More general terms

• transmembrane 6 protein
• aquaporin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=366
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:366
• OMIM: https://mirror.omim.org/entry/602914
• UniProt: http://www.uniprot.org/uniprot/O43315.html