aquaporin-8; AQP-8 (AQP8)

Function

• forms a water-specific channel
• mercury-sensitive
• not permeable to glycerol or urea

Structure

• aquaporins contain two tandem repeats each containing 3 membrane-spanning domains & a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)
• belongs to the MIP/aquaporin (TC 1.A.8) family

Compartment

membrane

Expression

expressed only in pancreas & colon

More general terms

• transmembrane 6 protein
• aquaporin
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=343
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:343
• OMIM: https://mirror.omim.org/entry/603750
• UniProt: http://www.uniprot.org/uniprot/O94778.html