aquaporin-6; AQP-6; aquaporin-2-like; kidney-specific aquaporin; hKID (AQP6, AQP2L)

Function

• forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis & acid-base metabolism (putative)

Structure

• aquaporins contain two tandem repeats each containing 3 membrane-spanning domains & a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)
• belongs to the MIP/aquaporin (TC 1.A.8) family

Compartment

cytoplasmic vesicle membrane

More general terms

• transmembrane 6 protein
• aquaporin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=363
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:363
• OMIM: https://mirror.omim.org/entry/601383
• UniProt: http://www.uniprot.org/uniprot/Q13520.html