ornithine decarboxylase antizyme 3; AZ3; ODC-Az 3 (OAZ3)

Function

• binds to, & destabilizes, ornithine decarboxylase
• does not accelerate ornithine decarboxylase degeneration
• OAZ3 probably plays a role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells
• interacts with GGN (putative)

Structure

belongs to the ODC antizyme family

Compartment

• nucleus, cytoplasm (putative)

Expression

• testis specific
• expression starts early in spermiogenesis & terminates in late spermatid phase

Notes

• aribosomal frameshift occurs between the codons for Ser-28 & Glu-29
• an autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines

More general terms

• ornithine decarboxylase antizyme
• nuclear protein
• testis-specific protein

Additional terms

• antizyme inhibitor 1; AZI; ornithine decarboxylase antizyme inhibitor (AZIN1, OAZI, OAZIN)
• ornithine decarboxylase 1

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51686
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51686
• OMIM: https://mirror.omim.org/entry/605138
• UniProt: http://www.uniprot.org/uniprot/Q9UMX2.html