calcipressin-2; Down syndrome candidate region 1-like 1; myocyte-enriched calcineurin-interacting protein 2; MCIP2; regulator of calcineurin 2; thyroid hormone-responsive protein ZAKI-4 (RCAN2, DSCR1L1, ZAKI4)

Function

• inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A
• could play a role during central nervous system development

Structure

belongs to the RCAN family

Alternative splicing

named isoforms=2

Expression

• expressed in fibroblasts, heart, brain, liver, & skeletal muscle
• not expressed in placenta, lung, kidney or pancreas
• induced by thyroid hormone

More general terms

• calcipressin

Additional terms

• calcineurin; serine/threonine protein phosphatase 3 (formerly PP2B)
• Down's syndrome
• myocyte
• thyroid hormone

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10231
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10231
• OMIM: https://mirror.omim.org/entry/604876
• UniProt: http://www.uniprot.org/uniprot/Q14206.html