S-arrestin; retinal S-antigen; S-AG; 48 kD protein; Rod photoreceptor arrestin (SAG)
Jump to navigation
Jump to search
Function
- arrestin is one of the major proteins of the retinal rod outer segments
- it binds to photoactivated, phosphorylated rhodopsin, thus apparently preventing the transducin-mediated activation of phosphodiesterase
- arrestin binds Ca+2
Structure
belongs to the arrestin family
Expression
Pathology
- S-antigen induces autoimmune uveitis
- defects in SAG are a cause of congenital stationary night blindness Oguchi type
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P10523.html
- ↑ Mutations of the SAG gene Retina International's scientific newsletter http://www.retina-international.com/sci-news/sagmut.htm
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=SAG
- ↑ Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ. beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science. 1990 Jun 22;248(4962):1547-50. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2163110
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6295