dermokine (epidermis-specific secreted protein SK30/SK89, DMKN)

Function

• may act as a soluble regulator of keratinocyte differentiation (putative)

Structure

• O-glycosylated
• homooligomer, seems to be able to homodimerize & homotrimerize
• belongs to the dermokine family

Compartment

secreted

Alternative splicing

named isoforms=15

Expression

• expressed in epidermis; in the spinous & granular layers
• expressed in placenta
• found in the epithelia of the small intestine, macrophages of the lung & endothelial cells of the lung
• isoform 15 is expressed in epidermis & placenta &
• isoform 1 is expressed in epidermis

More general terms

• secreted protein
• paracrine hormone

Database

• UniProt: http://www.uniprot.org/uniprot/Q6E0U4.html