Minor histocompatibility protein HB-1 ([contains: Minor histocompatibility antigen HB-1 (mHag HB-1)], HMHB1)

Function

• precursor of the minor histocompatibility antigen HB-1
• induces cell recognition & lysis by CTL
• owever HB-1 restricted expression in B-ALL cells & not in normal tissues may allow a specific CTL reactivity against B-ALL without the risk of evoking graft-versus-host disease
• HB-1 forms a complex with MHC class 1 HLA-B44

Expression

• expressed in acute lymphoblastic leukemia B- cells & Epstein-Barr virus-transformed B-cells

More general terms

• minor histocompatibility antigen

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5782
• UniProt: http://www.uniprot.org/uniprot/O97980.html