tumor-associated Ca+2 signal transducer 2; pancreatic carcinoma marker protein GA733-1; cell surface glycoprotein trop-2 (TACSTD2, GA733-1, M1S1, TROP2)

Function

• may function as a growth factor receptor
• the N-terminus is blocked

Structure

• belongs to the EPCAM family
• contains 1 thyroglobulin type-1 domain

Compartment

• membrane; single-pass type 1 membrane protein

Expression

placenta, pancreatic carcinoma cell lines

Pathology

• defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy

More general terms

• glycoprotein
• tumor (cancer or CA) antigen
• membrane protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P09758.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4070
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4070
• OMIM: https://mirror.omim.org/entry/137290
• OMIM: https://mirror.omim.org/entry/204870