epithelial cell adhesion molecule; Ep-CAM; tumor-associated Ca+2 signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; epithelial cell surface antigen; epithelial glycoprotein; EGP; epithelial glycoprotein 314; EGP314; hEGP314; adenocarcinoma-associated antigen; KSA; KS 1/4 antigen; cell surface glycoprotein trop-1; CD326 (EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1)
Jump to navigation
Jump to search
Function
- may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) & intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection
Structure
- monomer
- belongs to the EPCAM family
- contains 1 thyroglobulin type-1 domain
Compartment
- membrane; single-pass type 1 membrane protein
Expression
- expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes
- found on the surface of adenocarcinomas
Pharmacology
- target of sacituzumab govitecan-hziy (Trodelvy), a drug FDA-approved for refractory triple-negative breast cancer
Laboratory
- circulating tumor cell count identifies & quantifies EpCAM produced by epithelial tumor cells (carcinomas)[3]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P16422.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/TACSTD1ID42459ch2p21.html
- ↑ Jump up to: 3.0 3.1 ARUP Consult: Circulating Tumor Cell Count https://arupconsult.com/ati/circulating-tumor-cell-count