blood group Rh(CE) polypeptide; rhesus C/E antigens; Rh30A; RhIXB; Rh polypeptide 1; RhPI; CD240CE (RHCE, RHC RHE)

Function

• may be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane

Structure

• belongs to the ammonium transporter (TC 2.A.49) family, Rh subfamily

Compartment

membrane

Alternative splicing

named isoforms=13; RHI; RHIV;; RHVI;; RHVIII

Expression

• restricted to tissues or cell lines expressing erythroid characters

Polymorphism

• RhCE & RhD are responsible for the RH blood group system.
• the molecular basis of the E=Rh3/e=Rh5 blood group antigens is a single variation in position 226
  • Pro-226 corresponds to Rh3 & Ala-226 to Rh5
• the molecular basis of the C=Rh2/c=Rh4 blood group antigens is a single variation in position 103
  • Ser-103 corresponds to Rh2 & Pro-103 to Rh4

More general terms

• transmembrane 11 protein
• blood group antigen
• CD antigen

Database

• UniProt: http://www.uniprot.org/uniprot/P18577.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6006
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6006
• OMIM: https://mirror.omim.org/entry/111690
• OMIM: https://mirror.omim.org/entry/111700