protein phosphatase 1D (protein phosphatase 2C isoform delta, PP2C-delta, p53-induced protein phosphatase 1, protein phosphatase Mg+2-dependent 1 delta, PPM1D, WIP1)

Function

• required for the relief of p53-dependent checkpoint mediated cell cycle arrest
• binds to & dephosphorylates Ser-15 of TP53 & Ser-345 of CHEK1 which contributes to the functional inactivation of these proteins
• interacts with CHEK1

phosphoprotein + H2O = protein + phosphate

Cofactor: binds 2 Mg+2 or Mn+2 per subunit

Structure

• belongs to the PP2C family
• contains 1 PP2C-like domain

Expression

induced by p53

More general terms

• phosphoprotein phosphatase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8493
• OMIM: https://mirror.omim.org/entry/605100
• UniProt: http://www.uniprot.org/uniprot/O15297.html