integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP)

Function

• protein phosphatase
• role in regulation of cell cycle progression (putative)
• selectively associates with integrin linked kinase (ILK), to modulate cell adhesion & growth factor signaling
• inhibits ILK-GSK3B signaling axis
• role in inhibiting oncogenic transformation (putative)
• interacts with ILK
• specific association with ILK is independent of catalytic activity of either

phosphoprotein + H2O <--> protein + phosphate

Cofactor: binds Mn+2 per subunit

Inhibition:

• inhibited rather than stimulated by Mg+2
• binds 2 Mg+2 per subunit

Structure

• belongs to the PP2C family
• contains 1 PP2C-like domain

Compartment

cytoplasm

Expression

• widely expressed
• highest levels expressed in striated muscle
• much lower levels evident in various smooth muscle tissues
• inhibited rather than stimulated by Mg+2

More general terms

• phosphoprotein phosphatase

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H0C8.html