ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1)

Function

• may specifically dephosphorylate Ser-5 of heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit

phosphoprotein + H2O <--> protein + phosphate

Cofactor: Mg+2

Kinetic parameters:

• Optimum pH is 5.0

Structure

• contains 1 FCP1 homology domain
• contains 1 ubiquitin-like domain

Compartment

nucleus

Expression

• broadly expressed
• highest levels in placenta, lung, testis, ovary

Pathology

• up-regulated in tumor tissues

More general terms

• phosphoprotein phosphatase
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8WVY7.html