serine/threonine protein phosphatase dullard (DULLARD, CTDNEP1)

Function

• serine/threonine phosphatase
• may be required for proper nuclear membrane morphology
• involved in LPIN1 dephosphorylation
• may antagonize BMP signaling

phosphoprotein + H2O <--> protein + phosphate

Kinetic parameters:

• KM=18 mM for p-nitrophenylphosphate
• Optimum pH is 5.5

Structure

• belongs to the dullard family
• contains 1 FCP1 homology domain

Compartment

• endoplasmic reticulum membrane, nuclear envelope

More general terms

• membrane protein
• phosphoprotein phosphatase

Database

• UniProt: http://www.uniprot.org/uniprot/O95476.html