phosphatidylinositol-4-phosphate 5-kinase type-1 beta; PIP5K1-beta; Ptdins(4)P-5-kinase 1 beta; phosphatidylinositol-4-phosphate 5-kinase type I beta; PIP5KIbeta; protein STM-7; type I phosphatidylinositol-4-phosphate 5-kinase beta (PIP5K1B STM7)

Function

• mediates RAC1-dependent reorganization of actin filaments (putative)
• role in biosynthesis of phosphatidylinositol-4,5-bisphosphate

ATP + phosphatidylinositol-4-phosphate = ADP + phosphatidylinositol-4,5-bisphosphate

Structure

contains 1 PIPK domain

Compartment

• endomembrane system (putative)
• associated with the plasma membrane & endoplasmic reticulum

Alternative splicing

named isoforms=2

Expression

• expressed in heart, pancreas, brain, kidney, skeletal muscle & lung

More general terms

• phosphoinositide-5-kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8395
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8395
• OMIM: https://mirror.omim.org/entry/602745
• UniProt: http://www.uniprot.org/uniprot/O14986.html