transglutaminase-5 (TGM5, protein-glutamine gamma-glutamyltransferase X)

Function

• catalyzes the cross-linking of proteins & the conjugation of polyamines to proteins
• contributes to formation of the cornified cell envelope of keratinocytes

protein glutamine + alkylamine
               <-->
protein N(5)-alkylglutamine + NH3

Cofactor: binds 1 Ca+2 per subunit (putative)

Structure

• belongs to the transglutaminase superfamily transglutaminase family

Compartment

• cytoplasm
• associated with intermediate filaments

Alternative splicing

named isoforms=2

Expression

• expressed in foreskin keratinocytes
• induced by tetradecanoylphorbolacetate (TPA) & Ca+2 in NHEK cells

Pathology

• defects in TGM5 are a cause of peeling skin syndrome acral type

More general terms

• transglutaminase

Database

• OMIM: https://mirror.omim.org/entry/270300
• OMIM: https://mirror.omim.org/entry/603805
• UniProt: http://www.uniprot.org/uniprot/O43548.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9333