Na+/hydrogen exchanger 8; Na+/H+ exchanger 8; NHE-8; solute carrier family 9 member 8 (SLC9A8, KIAA0939, NHE8)

Function

• role in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions
• major proton extruding system driven by the inward Na+ chemical gradient
• role in signal transduction

Structure

• belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

Compartment

• Golgi membrane; multi-pass membrane protein

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• strongly expressed in skeletal muscle & kidney

More general terms

• solute carrier family 9 (SLC9, SLC9A)
• Na+/H+ antiporter
• transmembrane 11 protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23315
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23315
• OMIM: https://mirror.omim.org/entry/612730
• UniProt: http://www.uniprot.org/uniprot/Q9Y2E8.html