transient receptor potential cation channel subfamily M member 1 (long transient receptor potential channel 1, LTrpC1, melastatin-1, TRPM1, LTRPC1, MLSN, MLSN1)

Function

• Ca+2 channel
• may act as a spontaneously active, Ca+2-permeable plasma membrane channel
• mediates cation influx in HEK293 cells
• may play a role in suppression of metastasis

Structure

• belongs to the transient receptor family, LTrpC subfamily

Compartment

cell membrane

Alternative splicing

named isoforms=4

Expression

• highly expressed in benign melanocytic nevi
• expressed in melanocytes & pigmented metastatic melanoma cell lines
• in melanocytes expression appears to be regulated at the level of transcription & mRNA processing
• up-regulated by hexamethylene bisacetamide (HBMA)

Pathology

• diffusely expressed in various in situ melanomas, but not detected in melanoma metastases

More general terms

• Ca+2 channel
• phosphoprotein
• receptor
• transmembrane 9 protein

Database

• OMIM: https://mirror.omim.org/entry/603576
• UniProt: http://www.uniprot.org/uniprot/Q7Z4N2.html