receptor-type tyrosine-protein phosphatase O; R-PTP-O; glomerular epithelial protein 1; protein tyrosine phosphatase U2; PTP-U2; PTPase U2 (PTPRO, GLEPP1, PTPU2)

Function

• possesses tyrosine phosphatase activity

protein tyrosine phosphate + H2O = protein tyrosine + phosphate

Structure

• belongs to the protein-tyrosine phosphatase family receptor class 3 subfamily
• contains 8 fibronectin F3 modules
• contains 1 tyrosine-protein phosphatase domain

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=2

Expression

• glomerulus of kidney
• also detected in brain, lung & placenta
• induced by various differentiation-inducing agents

More general terms

• tyrosine phosphatase, receptor type
• receptor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5800
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5800
• OMIM: https://mirror.omim.org/entry/600579
• UniProt: http://www.uniprot.org/uniprot/Q16827.html