transcription factor-like 5 protein (Cha transcription factor, HPV-16 E2-binding protein 1, E2BP-1, TCFL5, CHA, E2BP1)

Function

• transcription factor (putative)
• isoform 1 may play a role in early spermatogenesis
• efficient DNA binding requires dimerization with another bHLH protein

Structure

• contains 1 basic helix-loop-helix (bHLH) domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• isoform 1 is testis specific it is specifically expressed in primary spermatocytes at the pachytene stage, but not those at leptonema stage not expressed in other testicular cells, including spermatogonia located in the basal compartment of the seminiferous tubule or spermatids.
• isoform 2 is pancreas specific

Pathology

• antibodies against TCFL5 are present in sera from patients with Chagas' disease

More general terms

• transcription factor (TF)
• DNA-binding protein

Database

• OMIM: https://mirror.omim.org/entry/604745
• UniProt: http://www.uniprot.org/uniprot/Q9UL49.html