myelin transcription factor-1; proteolipid protein-binding protein (MYT1, PLPB1, MTF1, MYTI, KIAA0835, KIAA1050)

Function

• binds to the promoter regions of proteolipid proteins of the central nervous system
• may play a role in development of neurons & oligodendrogalia in the CNS
• may regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation & up-regulation of myelin gene transcription
• interacts with STEAP3

Structure

• contains 7 C2HC-type Zn+2 fingers arranged in 2 widely separated clusters; these 2 domains of DNA binding can function independently & recognize the same DNA sequence

Compartment

nucleus

Expression

• mostly in developing nervous system
• expressed in neural progenitors & oligodendrocyte lineage cells
• more highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes

More general terms

• DNA-binding protein
• transcription factor (TF)
• zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q01538.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4661
• OMIM: https://mirror.omim.org/entry/600379