nucleoside diphosphate kinase-A, (NDP kinase A, tumor metastatic process-associated protein, metastasis inhibition factor nm23, nm23-H1, NME1, nm23/H1 nucleoside diphosphate kinase, granzyme A-activated DNase, GAAD)

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Function

  • major role in the synthesis of nucleoside triphosphates other than ATP
  • potential negative regulator of cancer metastasis
  • interacts with SET
  • N-terminus is blocked
ATP + nucleoside diphosphate <--> ADP + nucleoside triphosphate

Cofactor: Mg+2

Structure

  • hexamer of two different chains: A & B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6)
  • belongs to the NDK family

Compartment

cytoplasm, nucleus

Pathology

More general terms

References

  1. Postel EH, Berberich SJ, Flint SJ, Ferrone CA. Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. Science. 1993 Jul 23;261(5120):478-80. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8392752
  2. UniProt http://www.uniprot.org/uniprot/P15531.html

Database