methionine adenosyltransferase 2 subunit beta (MAT2-beta, DTDP-4-keto-6-deoxy-D-glucose 4-reductase, MAT2B, TGR)

Function

• non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2
• regulates activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S-adenosylmethionine inhibition

Structure

• belongs to the dTDP-4-dehydrorhamnose reductase family, MAT2B subfamily

Alternative splicing

named isoforms=5

Expression

• widely expressed

Pathology

• expression in hepatoma cell lines may lead to increase DNA synthesis, thus increase cell proliferation

More general terms

• enzyme regulatory subunit

Component of

• methionine adenosyltransferase 2 (S-adenosylmethionine synthetase 2)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2743
• OMIM: https://mirror.omim.org/entry/605527
• UniProt: http://www.uniprot.org/uniprot/Q9NZL9.html