glutamate-cysteine ligase regulatory subunit; gamma-glutamylcysteine synthetase regulatory subunit (GCLM)

Function

• sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine & L-glutamate: step 1/2

Structure

• heterodimer of a catalytic heavy chain & a regulatory light chain
• belongs to the aldo/keto reductase family, glutamate-cysteine ligase light chain subfamily

Expression

• expressed in all tissues examined
• highest levels in skeletal muscle

More general terms

• enzyme regulatory subunit

Component of

• glutamate-cysteine ligase; gamma-glutamylcysteine synthetase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2730
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2730
• OMIM: https://mirror.omim.org/entry/601176
• UniProt: http://www.uniprot.org/uniprot/P48507.html