adducin 3 (gamma adducin, ADDL, adducin-like protein 70)

Function

• membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network
• binds to calmodulin
• sumoylated

Structure

• heterodimer of an alpha & a gamma subunit
• comprised of three regions:
  • N-terminal protease-resistant globular head region
  • a short connecting subdomain
  • a protease-sensitive tail region
• belongs to the aldolase class II family, adducin subfamily

Compartment

• cytoplasm, cytoskeleton, cell membrane
• peripheral membrane protein; cytoplasmic side

Alternative splicing

named isoforms=2 additional isoforms seem to exist

Expression

heart only expresses isoform 1

More general terms

• protein subunit
• membrane protein
• calmodulin binding protein
• phosphoprotein

Component of

• adducin

Database

• OMIM: https://mirror.omim.org/entry/601568
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=120
• UniProt: http://www.uniprot.org/uniprot/Q9UEY8.html