serine/threonine protein phosphatase 2A regulatory subunit B subunit gamma (protein phosphatase subunit G5PR, rhabdomyosarcoma antigen MU-RMS-40.6A, rhabdomyosarcoma antigen Mu-RMS-40.6C, PPP2R3C, C14orf10, G5PR)

Function

• may regulate MCM3AP phosphorylation through phosphatase recruitment.
• role in the activation-induced cell death of B-cells (putative)
• interacts with MCM3AP/GANP
• interacts with PPP5C, & phosphatase 2A core enzyme

Structure

contains 2 EF-hand domains

Compartment

• nucleus, cytoplasm
• excluded from nucleoli
• localization is cell cycle-dependent
• localizes to cytoplasm during cytokinesis

Alternative splicing

named isoforms=1

Expression

• ubiquitously expressed in brain & other tissues
• expressed in fetal brain

More general terms

• enzyme regulatory subunit
• Ca+2 binding protein

Component of

• phosphatase-2A (ceramide-activated protein phosphatase)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5501
• UniProt: http://www.uniprot.org/uniprot/Q969Q6.html