transient receptor potential cation channel subfamily M member 3 (TrpM3, long transient receptor potential channel 3, LTrpC3, melastatin-2, MLSN2, KIAA1616)
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Function
- constitutive Ca+2 channel
- activity increased by
- decreased extracellular osmolarity
- muscarinic receptor activation
Compartment
membrane
Alternative splicing
named isoforms=10
Expression
- expressed kidney > brain, testis, ovary, pancreas, spinal cord
- in the kidney, expressed predominantly in collecting tubular epithelium in the renal medulla, medullary rays & periglomerular regions
- in the brain, expression greatest in cerebellum, choroid plexus, locus coeruleus, posterior thalamus, substantia nigra
Pathology
- down-regulated in renal tumors compared to normal kidney
More general terms
- transient receptor potential cation channel subfamily M (TRPM)
- Ca+2 channel
- Na+ channel
- transmembrane 7 protein