transient receptor potential cation channel subfamily V member 3 (TrpV3, vanilloid receptor-like 3, VRL-3)

Function

• receptor-activated non-selective Ca+2 channel
• activated by innocuous (warm) temperatures
• shows increased response at noxious temperatures greater than 39 degrees Celsius
• activation exhibits an outward rectification
• may associate with TRPV1 & may modulate its activity
• may form a heteromeric channel with TRPV

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• expressed in CNS, dorsal root ganglion,
• widely expressed at low levels

More general terms

• transient receptor potential cation channel subfamily V (TRPV)
• Ca+2 channel
• transmembrane 6 protein
• phosphoprotein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/607066
• UniProt: http://www.uniprot.org/uniprot/Q8NET8.html