solute carrier family 23 member 1; Na+ dependent vitamin C transporter 1; hSVCT1; Na+/L-ascorbic acid transporter 1; yolk sac permease-like molecule 3 (SLC23A1, SVCT1, YSPL3)

Function

• Na+/ascorbate cotransporter. mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate
• phosphorylated (probable)

Structure

• belongs to the xanthine/uracil permease family, SLC23A subfamily

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate & liver, & in fetal kidney, liver & thymus
• treatment with the protein kinase C stimulator PMA results in a 10-fold decrease in ascorbate accumulation in transfected cells

More general terms

• symporter
• glycoprotein
• solute carrier family 23 (SLC23, SLC23A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9963
• OMIM: https://mirror.omim.org/entry/603790
• UniProt: http://www.uniprot.org/uniprot/Q9UHI7.html