eosinophil lysophospholipase; Charcot-Leyden crystal protein; lysolecithin acylhydrolase; galectin-10 (CLC)

Function

• may have both lysophospholipase & carbohydrate-binding activities

2-lysophosphatidylcholine + H2O
             <-->
glycerophosphocholine + a carboxylate

Structure

contains 1 galectin domain

Compartment

• cytoplasmic granule
• localized in granules from where it may be secreted or transported to other locations in the cell

Expression

• expressed exclusively by eosinophils & basophils
• not detected in monocytes & neutrophils

Pathology

• forms hexagonal bipyramidal crystals, known as Charcot-Leyden crystals, in tissues & secretions from sites of eosinophil-associated inflammation & some myeloid leukemias

More general terms

• lysophospholipase
• galaptin

Additional terms

• eosinophil lysophospholipase; Charcot-Leyden crystal protein; lysolecithin acylhydrolase; galectin-10 (CLC)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1178
• UniProt: http://www.uniprot.org/uniprot/Q05315.html
• OMIM: https://mirror.omim.org/entry/153310
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1178