serpin B11

Function

• no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change

Structure

belongs to the serpin family, Ov-serpin subfamily

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=3

Expression

• detected in a restricted number of tissues, including lung, placenta, prostate, & tonsil

Pathology

• mutations in the scaffold leading to either a stop codon instead of a Glu at position 90, an Arg instead of the well conserved Trp at position 188, or a Pro instead of Ser at position 303 lead to the loss of inhibitory activity

Polymorphism

according to some authors,

• 4 of the identified SERPIN11 transcripts contain coding sequences distinguished by different combinations of single nucleotide polymorphisms (SERPINB11a, SERPINB11b, SERPINB11c, & SERPINB11d), & one contained
• a nonsense mutation introduces a premature stop codon in position 90 (SERPINB11f)

More general terms

• serine protease inhibitor; serpin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=89778
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:89778
• UniProt: http://www.uniprot.org/uniprot/Q96P15.html